- 1991
- The Ministry of Education, Science, Sports, and Culture started the Human Genome Project and Human Genome Center (Laboratory of Genome Database) was established as its standard-bearer.
- 1992
- Laboratory of Structure Genomics started. A prefabricated building of the center was completed.
- 1993
- A super parallel computer system was introduced. Laboratory of DNA Information Analysis started.
- 1996
- The MESSC human genome project proceeded from its first stage to the second stage. Laboratory of Molecular Medicine and Laboratory of Genome Technology started.
- 1997
- The main building of Human Genome Center was completed. A supercomputer system for genome informatics was introduced.
- 2000
- Laboratory of Sequence Analysis and Laboratory of Functional Analysis in silico started.
- 2003
- The building of multidisciplinary research was completed.

